Macromolecules: Contemporary Futurist Thoughts on Progressive Journey

Progressive thoughts about progressive disease.

In this issue of Clinical Cancer Research , Desai et al. (1) present evidence that new modules appearing in preexisting lesions can represent clonally resistant populations. Imatinib mesylate, the prototypic oral tyrosine kinase inhibitor that has activity against ABL, KIT, and platelet-derived growth factor receptor kinases arguably represents the most important oncologic advance of the past 3...

A “Futurist” approach to dynamic environments

The optimization of dynamic environments has proved a difficult area for Genetic Algorithms. As standard haploid populations find it difficult to track a moving target, different schemes have been described to improve on the situation. We propose a novel approach by making use of a metalearner which tries to predict the next state of the environment, i.e. the next value of the goal the individu...

An investigation of futurist architectural design

This paper explores the relations between drawing and its influences on architectural language. It uses as a resource the examination of the so-called futurist architecture, above all, the graphic production of Antonio Sant’Elia. The interest of the study lies in the verification that, despite the futurist movement having failed to erect a single work of architecture as representative of its id...

Editorial: Some thoughts on progressive transmission of spatial datasets in the web environment

Powder crystallography on macromolecules.

Following the seminal work of Von Dreele, powder X-ray diffraction studies on proteins are being established as a valuable complementary technique to single-crystal measurements. A wide range of small proteins have been found to give synchrotron powder diffraction profiles where the peak widths are essentially limited only by the instrumental resolution. The rich information contained in these ...